Dr. Debajyoti De

Dr. Debajyoti De is an experimental physicist specializing in soft condensed matter physics and biophysics. He holds a Ph.D. in Soft Condensed Matter and Biophysics from the Department of Physics, IIT Kharagpur. He obtained his Master's degree in Physics from Visva-Bharati University and his Bachelor's degree in Physics from the University of Burdwan. His academic training combines the fundamental principles of physics, including quantum mechanics and statistical physics, with modern approaches to understanding complex biological systems.

Prior to joining Alliance University as an Assistant Professor, Dr. De served as a Postdoctoral Research Associate at the University of Birmingham, United Kingdom, and as a Postdoctoral Fellow at TIFR Hyderabad. He also worked as an Assistant Professor of Physics at MAEER's MIT, Thane.

Dr. De's research lies at the interface of soft condensed matter physics and biophysics. His work focuses on understanding the structure, dynamics, and conformational behaviour of biomolecular systems across a wide range of timescales using advanced spectroscopic and scattering techniques. His primary expertise is in biomolecular NMR spectroscopy, complemented by light scattering, circular dichroism, fluorescence spectroscopy, and other biophysical methods. He is also interested in exploring interdisciplinary applications of quantum science and artificial intelligence to complex problems in physics and biomolecular systems.

Dr. De has authored several research articles in leading international peer-reviewed journals, including Proceedings of the National Academy of Sciences, ACS Applied Bio Materials, and Physical Chemistry Chemical Physics. He has presented his research at numerous national and international conferences and has collaborated with researchers across India, Canada, Japan and the United Kingdom. As an educator, he is committed to concept-driven, student-centred teaching that integrates theory with experimental practice. He actively promotes interdisciplinary learning and aims to inspire students to apply the principles of physics while fostering connections between quantum science, artificial intelligence, biology, and materials science, thereby contributing to a strong research culture in higher education.

Publication:

• Megha N. Karanth, Debajyoti De, John Kirkpatrick, Mark Jeeves, Teresa Carlomagno ‘Slow dynamics orchestrate communication between binding sites in the condensation domain of a non-ribosomal peptide synthetase’, (JMB 169484, 2025)
• Debajyoti De, Nemika Thapliyal, Ved Prakash Tiwari, Yuki Toyama, D Flemming Hansen, Lewis E Kay, Pramodh Vallurupalli ‘Mapping the FF domain folding pathway via structures of transiently populated folding intermediates’, (PNAS 121 (50), 2024)
• Ved P Tiwari, Debajyoti De, Nemika Thapliyal, Lewis E Kay, Pramodh Vallurupalli ‘Beyond slow two-state protein conformational exchange using CEST: applications to three-state protein interconversion on the millisecond time scale’, ( Biomol. NMR 1-22, 2024)
• Ved P Tiwari, Yuki Toyama, Debajyoti De, Lewis E Kay, Pramodh Vallurupalli ‘The A39G FF domain folds on a volcano-shaped free energy surface via separate pathways’, (PNAS 118 (46), 2021)
• Kumari Shikha, G Sriram Bharath, Swagata Mukhopadhyay, Mayukh Chakraborty, Susmita Ghosh, Suparna Khatun, Debajyoti De, Amar Nath Gupta, and Agneyo Ganguly; ‘The catalytic core of Leishmania donovani RECQ helicase unwinds a wide spectrum of DNA substrates and is stimulated by replication protein A’ (FEBS J 289(2):394-416, 2021)
• Debabrata Mandal, Sudipta Biswas, Ananya Chowdhury, Debajyoti De, Chandra Tiwary, Amar Nath Gupta, Trilok Singh, Amreesh Chandra; ‘Hierarchical cage-frame type nanostructure of CeO2 for bio sensing applications: From glucose to protein detection’ (Nanotechnology 32 (2), 025504, 2021)
• Debajyoti De, Nisha Pawar, and Amar Nath Gupta; ‘Electric Field-induced Structural Transitions of Elastin’, ( Chem. Chem. Phys. 23 (7), 4195-4204, 2021)
• Debajyoti De, Chandan Kanta Das, Debabrata Mandal, Mahitosh Mandal, Nisha Pawar, Amreesh Chandra, and Amar Nath Gupta; ‘Curcumin complexed with graphene derivative for breast cancer therapy’, (ACS Appl. Bio Mater. 3(9):6284-6296, 2020)
• Debajyoti De, Anurag Singh, and Amar Nath Gupta; ‘Unveiling the Transition Path Region in the One-dimensional Free Energy Landscape of Proteins’, ( Phys. Lett. 750:137498, 2020)
• Debajyoti De, Nisha Pawar, and Amar Nath Gupta; ‘Glucose-induced Structural Changes and anamolous diffusion of elastin’, (Colloids Surf. B Biointerfaces. 188:110776, 2020)

CONFERENCE PRESENTATIONS:

• Structure, dynamics and interactions in biomolecular systems using NMR spectroscopy (EMBO-2022, IISER Berhampur), titled ‘The Small FF domains fold via multiple paths and multiple intermediates’.
• International Conference on Advances in Biological Systems and Material Science in Nano World (ABSMSNW-2017, IIT-BHU), titled ‘Analysis of Folding Energy Landscape for a Single Domain Protein’.
• Gordon Research Conference on Protein Folding Dynamics (GRC-2018, TX, United States), titled ‘Accurate Estimation of Transition Path Region: Asymmetry in the Free Energy Landscape as Measure of Conformational Freedom’.
• International Conference on Complex Fluids and Soft Matter, (COMPFLU-2018, IIT-Roorkee), titled ‘Breast Cancer Therapy and Cell imaging using Curcumin-Loaded Graphene Derivative’.